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Non-Invasive Prenatal Test (NIPT)

for Fetal RhD Status

Non-Invasive Prenatal Test (NIPT) for Fetal RhD Status is used to non-invasively predict the RhD Status of the fetus by analysing cell-free fetal DNA (cffDNA) in the maternal plasma.

What is Rhesus D?

Antigens are protein variants which the immune system can recognise. "Rh" refers to the Rhesus antigen system. There are several different Rh antigens, one of it is Rh (D). 

What is RhD negative and RhD positive?

Why is the Rh status important for pregnancy?

A person carrying blood that have Rh (D) antigens present are called "positive" and ones that do not have Rh (D) antigens present are called "negative".

During pregnancy, if a fetus is Rh (D) positive and the mother is Rh (D) negative, the mother may make antibodies to attack the baby's red cells. These antibodies can destroy the fetal red cells leading to anaemia in the fetus. This is called Haemolytic Disease of the Newborn (HDN).

Ordering the test can only be rendered after adequate assessment of your condition and discussion with your clinician.

1.     Saramago et al., High-throughput non-invasive prenatal testing for fetal rhesus D status in RhD-negative women not known to be sensitised to the RhD antigen: A systematic review and economic evaluation. Health Technology Assessment. 22. 2018; 1-172 2.    

2.      de Haas et al., Anti-D prophylaxis: past present and future. Transfus Med 2014:24:1-7. 3.   

3.       NICE Diagnostics guidance [DG25l High-throughput non-invasive prenatal testing for fetal RHD genotype. 2016 

Medical treatment has to be individualised and can only be rendered after adequate assessment of your condition through appropriate clinical examination, and after discussion with your clinician.